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Metformin also increases your body's response to insulin, Metformin may decrease the risk of lactic acidosis while you are taking this medicine. If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. Glucophage is used to control blood sugar levels. If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal. Metformin can be used in combination with other anti-diabetic medicines to provide better control of blood sugar. Diabetes develops when the body proves unable to burn sugar and the unused sugar builds up in the bloodstream. Metformin decreases the amount of sugar produced by cells in the liver.